HistoAtlas – Pan-cancer morphology atlas linking tissue features to molecular data and survival

Summary: HistoAtlas is a free web atlas that maps cancer tissue morphology from 6,745 TCGA H&E-stained slides to molecular programs and patient outcomes across 21 cancer types. It extracts 38 quantitative histomic features and precomputes over 10,000 statistical associations connecting tissue architecture with genes, pathways, mutations, immune subtypes, and clinical data.

What it does

HistoAtlas analyzes diagnostic slides to quantify tumor morphology, immune infiltration, spatial organization, and cell densities, then provides an interactive interface to explore associations with molecular and clinical variables.

Who it's for

Researchers and clinicians seeking to systematically explore links between cancer tissue morphology, molecular profiles, and patient survival across multiple cancer types.

Why it matters

It addresses the lack of tools connecting histopathology with genomics and clinical outcomes, enabling integrative analysis of cancer tissue architecture.